July 2022
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Copyright: Simone Reukauf
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BIO
Caroline studied Biology at the University of Bayreuth and received her PhD from the University of Kassel in 2010. During her PhD in the lab of Prof. Markus Maniak she isolated lipid droplets from the model organism Dictyostelium discoideum and characterized the lipid droplet proteome.
In 2011, Caroline started her postdoc in the lab of Prof. Thierry Soldati at the University of Geneva, Switzerland. During the first years, she used the D. discoideum / M. marinum infection system to study lipid droplet dynamics during mycobacteria infection.
2016 she was promoted “maître assistante” and established several tools to monitor lipid flows from D. discoideum to intracellular mycobacteria. Besides lipid metabolism, Caroline also worked on zinc and ZnT transporters and their role in the bactericidal defense of D. discoideum and during mycobacteria infection.
In September 2019, Caroline started the junior research group Molecular Infection Biology at the University of Osnabrück, Germany. The main research interest of the group is to unravel the molecular mechanisms by which intracellular mycobacteria acquire host lipids.
Caroline studied Biology at the University of Bayreuth and received her PhD from the University of Kassel in 2010. During her PhD in the lab of Prof. Markus Maniak she isolated lipid droplets from the model organism Dictyostelium discoideum and characterized the lipid droplet proteome.
In 2011, Caroline started her postdoc in the lab of Prof. Thierry Soldati at the University of Geneva, Switzerland. During the first years, she used the D. discoideum / M. marinum infection system to study lipid droplet dynamics during mycobacteria infection.
2016 she was promoted “maître assistante” and established several tools to monitor lipid flows from D. discoideum to intracellular mycobacteria. Besides lipid metabolism, Caroline also worked on zinc and ZnT transporters and their role in the bactericidal defense of D. discoideum and during mycobacteria infection.
In September 2019, Caroline started the junior research group Molecular Infection Biology at the University of Osnabrück, Germany. The main research interest of the group is to unravel the molecular mechanisms by which intracellular mycobacteria acquire host lipids.
PhD Students
MSc Anna-Carina Mazur
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BIO
Anna-Carina completed her BSc degree in Microbiology at the University of Osnabrück (with Prof. Hensel) where she studied the SiiAB and MotAB protein complexes that play a role for Salmonella adhesion and invasion of polarized epithelial cells.
After the successful completion of her BSc, she chose to continue her academic career in a master's program with a focus on Cell and Molecular Biology. For her MSc thesis she joined the group of Dr. Caroline Barisch in September 2021. As a PhD student of the SFB1557 ("functional plasticity encoded by cellular membrane networks") she is currently working on the exiting topic of lipid transfer proteins and how they are exploited by mycobacteria during infection.
Anna-Carina completed her BSc degree in Microbiology at the University of Osnabrück (with Prof. Hensel) where she studied the SiiAB and MotAB protein complexes that play a role for Salmonella adhesion and invasion of polarized epithelial cells.
After the successful completion of her BSc, she chose to continue her academic career in a master's program with a focus on Cell and Molecular Biology. For her MSc thesis she joined the group of Dr. Caroline Barisch in September 2021. As a PhD student of the SFB1557 ("functional plasticity encoded by cellular membrane networks") she is currently working on the exiting topic of lipid transfer proteins and how they are exploited by mycobacteria during infection.
MSc Sylvana Hüttel
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BIO
Sylvana pursued her MSc at the University of Munich and she performed two research internships in England and Munich to get specialized in Infection Biology. The project at the Bob Champions Research Institute of the University of East Anglia dealt with the influence of enterohaemorrhagic Escherichia coli and their outer membrane vesicles on human macrophages. Furthermore, she investigated the infection processes of human adenovirus at the Department of Molecular Virology of Helmholtz Institute of Neuherberg. From this point on, she wanted to know more about host-pathogen interactions, which is why she started her PhD in April 2021 in the group of Caroline Barisch within the DFG priority program "Exit strategies of intracellular pathogens" (SPP2225).
Sylvana pursued her MSc at the University of Munich and she performed two research internships in England and Munich to get specialized in Infection Biology. The project at the Bob Champions Research Institute of the University of East Anglia dealt with the influence of enterohaemorrhagic Escherichia coli and their outer membrane vesicles on human macrophages. Furthermore, she investigated the infection processes of human adenovirus at the Department of Molecular Virology of Helmholtz Institute of Neuherberg. From this point on, she wanted to know more about host-pathogen interactions, which is why she started her PhD in April 2021 in the group of Caroline Barisch within the DFG priority program "Exit strategies of intracellular pathogens" (SPP2225).
MSc Aby Anand
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BIO
Aby studied Biotechnology at the Karunya University in India and then came to Germany for higher education. He graduated with a MSc degree in Biosciences at the Julius Maximilians University of Würzburg. For hist master project, he succeeded in achieving the study completion grant from the German Academic Exchange Service (DAAD) and performed his master thesis in Molecular Infection Biology with the group of Roy Gross at the Biocenter, Würzburg. The objective of his master thesis was to investigate the role of dermonecrotic toxin of Bordetella pertussis, the pathogen which causes pertussis, in the interaction with human bronchial epithelial cells. Therefore, he infected monolayers of airway cells and engineered 3D tissue models. He became very interested in understanding the molecular mechanisms underlying host-pathogen interactions. To acquire deeper knowledge in the field of infection biology, he joined the Barisch lab in June 2020 as a PhD student to work on mycobacterial infection using Dictyostelium discoideum as a model host.
Aby studied Biotechnology at the Karunya University in India and then came to Germany for higher education. He graduated with a MSc degree in Biosciences at the Julius Maximilians University of Würzburg. For hist master project, he succeeded in achieving the study completion grant from the German Academic Exchange Service (DAAD) and performed his master thesis in Molecular Infection Biology with the group of Roy Gross at the Biocenter, Würzburg. The objective of his master thesis was to investigate the role of dermonecrotic toxin of Bordetella pertussis, the pathogen which causes pertussis, in the interaction with human bronchial epithelial cells. Therefore, he infected monolayers of airway cells and engineered 3D tissue models. He became very interested in understanding the molecular mechanisms underlying host-pathogen interactions. To acquire deeper knowledge in the field of infection biology, he joined the Barisch lab in June 2020 as a PhD student to work on mycobacterial infection using Dictyostelium discoideum as a model host.
MSc Stevanus Listian
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BIO
Stevanus pursued his MSc thesis at the Technical University of Denmark (DTU) where he enrolled in the Biotechnology program in 2017. During his master thesis, he worked under the supervision of Prof. Ákos T. Kovacs and studied the interaction between Bacillus subtilis with multiple fungal species and the potential of using the bacteria as a biocontrol agent. The master project was awarded with the Novo Scholarship in 2019 and he was given the opportunity to present his work at Novozymes A/S. In 2020, Stevanus started his PhD in the Barisch lab to study lipid trafficking during mycobacteria infection using the Dictyostelium-M. marinum model system. To this end, he uses tools such as lipidomics, TLC, live cell confocal microscopy and click-chemistry. He changed subject from environmental microbiology to host-pathogen interactions to broaden his knowledge and skills.
Stevanus pursued his MSc thesis at the Technical University of Denmark (DTU) where he enrolled in the Biotechnology program in 2017. During his master thesis, he worked under the supervision of Prof. Ákos T. Kovacs and studied the interaction between Bacillus subtilis with multiple fungal species and the potential of using the bacteria as a biocontrol agent. The master project was awarded with the Novo Scholarship in 2019 and he was given the opportunity to present his work at Novozymes A/S. In 2020, Stevanus started his PhD in the Barisch lab to study lipid trafficking during mycobacteria infection using the Dictyostelium-M. marinum model system. To this end, he uses tools such as lipidomics, TLC, live cell confocal microscopy and click-chemistry. He changed subject from environmental microbiology to host-pathogen interactions to broaden his knowledge and skills.
MSc Students
BSc Danica Müller
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BIO
Danica completed her BSc in the division of Zoology at the University of Osnabrück with Prof. Purschke. Her thesis was focused on the bioluminescence in marine annelids. She decided to continue her studies in the master's programme at the University of Osnabrück after successfully completing her BSc and joined the division of Molecular Infection Biology in November 2022. Her MSc project is focused on sphingomyelin-dependent membrane repair and its role in mycobacterial infection of macrophages.
Danica completed her BSc in the division of Zoology at the University of Osnabrück with Prof. Purschke. Her thesis was focused on the bioluminescence in marine annelids. She decided to continue her studies in the master's programme at the University of Osnabrück after successfully completing her BSc and joined the division of Molecular Infection Biology in November 2022. Her MSc project is focused on sphingomyelin-dependent membrane repair and its role in mycobacterial infection of macrophages.
BSc Edwin Ufelmann
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BIO
Edwin completed his BSc already in the Molecular Infection Biology division at the University of Osnabrück . The subject of his thesis was lipid transfer by VPS13 proteins and their possible role in mycobacterial infection. After completing his BSc, he continued his academic career in a master's program at the University of Osnabrück with a focus on Cell and Molecular Biology. For his MSc thesis, he re-joined the group of Dr. Caroline Barisch in January 2022. His current project deals with the development of a pipeline to monitor the impact of lipid-related drugs on mycobacteria infection.
Edwin completed his BSc already in the Molecular Infection Biology division at the University of Osnabrück . The subject of his thesis was lipid transfer by VPS13 proteins and their possible role in mycobacterial infection. After completing his BSc, he continued his academic career in a master's program at the University of Osnabrück with a focus on Cell and Molecular Biology. For his MSc thesis, he re-joined the group of Dr. Caroline Barisch in January 2022. His current project deals with the development of a pipeline to monitor the impact of lipid-related drugs on mycobacteria infection.
BSc Students
Michelle Hacker
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Fynn Kamp
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